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In the first phase, depolymerization of the filamentous subcortical actin barrier (F-actin) is required to rapidly release LDCVs 2

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This approval is conditional, requiring confirmation from part 2 of the ESSENCE trial before full approval is considered

Abstract Phosphodiesterase 1B (PDE1B) and phosphodiesterase 10A (PDE10A), members of the phosphodiesterase superfamily, are responsible for cyclic nucleotide hydrolysis, thereby regulating key intracellular signaling pathways such as cAMP response element-binding protein (CREB) activation and brain-derived neurotrophic factor (BDNF) gene transcription

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